Tribulus supplement product benefit and side effects, how to use it safely to improve male and female sexual health
What is the right dosage and extract potency?
November 25 2016

Review and benefits, where to purchase Tribulus supplement online at a reliable company
Tribulus is a plant long used around the world for the treatment of various ailments. it is popularly claimed to improve sexual function in humans. In Turkey, it is commonly used in folk medicine for the treatment of abdominal colic, hypertension and high cholesterol. In Europe it has been used in folk medicine throughout history for male and female sexual dysfunction. In China and India, tribulus has been touted for use in liver, kidney, urinary, and cardiovascular remedies

Tribulus supplement extract 500 mg, 60 Tablets, where to purchase
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Buy Tribulus extract or the more potent Passion Rx with Yohimbe

Aphrodisiac herbs that are potent
Additional sexual herbs and supplements that work include Maca herb, horny goat weed herbal extract, Tongkat Ali  and deer antler velvet. Side effects include insomnia and feeling hot.
Tongkat ali is quite potent, so is Passion Rx with Yohimbe.

Tribulus contains over 40% frustanol saponins, the active component. This south Asian herb is popular for its potent role in supporting reproductive function. Tribulus terrestris can be used by both men and women.
Tribulus 750 mg (minimum 40% frustanol saponins)

Natural sex product
Tribulus is a tropical vine common in sandy soil throughout India, Pakistan, and Sri Lanka. it contains furostanol saponins, the active component. This herb is popular for its potent role in supporting reproductive function. This herbal aphrodisiac can be used by both men and women.

Other products Source Naturals, Tribulus Extract, 750 mg, 60 Tablets
Supplement Facts: Tribulus 400 mg (standardized to 40 % saponins)

Ejaculation improvement
Q. Can tribulus terrestris lead to better ejaculations?
A. Yes, some people notice better ejaculations with tribulus, although tongkat ali works quite well, too.

Q.  I have read some studies that have shown many of these tribulus products only produce a placebo effect unless they are made from the leaf of the Tribulus terrestris plant. One study suggested that using 1500 mg/day, proved to be successful for many functions. Could you tell me about the tribulus terrestris product on your site and if it meets this criteria?
A. The tribulus terrestris product by Physician Formulas is an extract of 40 percent saponins. It is potent. One capsule is just right for most people and it may be a little too potent for those who are sensitive to herbs. We don’t suggest taking more than one capsule.

What’s in this herb?
The fruits contain a number of different substances including saponins (protodioscin, furostanol), glycosides, flavonoids, alkaloids, resins, tannins, sugars, sterols, and essential oil. Recently, two new saponins have been isolated from tribulus terrestris: Terrestrinins A and B.

Tribulus supplements available over the counter, online, iHerb, Amazon, Walgreen, Walmart, Whole Foods
Tribulus is most often found in combination with other sex-enhancing herbs in various libido products. It is also sold by itself often in a dosage ranging from 250 to 750 mg. Tribulus is found in a variety of extract potencies. Some examples of tribulus extracts include 20 percent saponins, 40 percent saponins, 45 percent saponins, 60 percent saponins, 20 percent protodioscin, 40 percent protodioscin. Gokshura is the Ayurvedic herb name for tribulus.

Tribex Gold 50 product
Q. I have just recently started taking 500 mg 2 times a day in the form of Tribex Gold 50. I am cycling 5 days on-two days off. I have had erectile dysfunction for about a year, with high blood pressure, which is now normal with meds. Would it hurt to add Passion Rx to my regime? I am desperate to return to full erections.
A. We don’t suggest using Passion Rx the same day as tribulus but they can be alternated.

Best tribulus extract product
Q. I have seen a number of tribulus extract products on the market. How do I know which extract concentration is best?
A. You are right that there are a number of different tribulus extract potencies. Human studies have not been done comparing different extract strengths to see which is best for erectile function. Your best option at this time is to try different tribulus extract products to see which one works best for you.

Sexual herbs and supplements that are effective in improving stamina and performance
Additional sexual herbs that have an influence on sexuality include: Ashwagandha herb, avena sativa, butea superba, Catuaba herb, cnidium monnieri, coleus forskohlii, damiana, Deer Antler Velvet extract, fish oils, Horny-Goat-Weed herb, Maca herb, Mucuna Pruriens herb, Muira Puama herb, Rhodiola herb, Tongkat-Ali, and Yohimbe.

Dosage and dose
I’ve got a question regarding the dosage on tribulus sex pill product. What is the right tribulus terrestris dosage for long term use?
The dosage can vary between individuals and at different times. The idea is to use it the least amount and dosage that works. This could be as little as once or twice a week but no more than 4 times a week. Tribulus terrestris dosage also depends on what other supplements or medications a person is taking.

Athletic performance, and testosterone effect
Does tribulus terrestris have an influence on testosterone release or enhance testosterone production? A human study done in Australia in 2007 did not find TT to have a major influence on muscle mass growth, nor did tribulus seem to influence blood testosterone levels in humans to any great extent. Animal and human studies have shown conflicting results in regards to the influence of tribulus terrestris supplements and testosterone levels.

J Ethnopharmacol. 2015. Pro-sexual and Androgen Enhancing Effects of Tribulus terrestris: Fact or Fiction. Historically, aphrodisiacs have had a reputation for making sex more achievable and satisfying. It has been long believed that Tribulus terrestris possesses aphrodisiac properties purportedly attributed to its ability to influence levels or mimic function of sex hormones. Due to this appealing beliefs, the popularity of medicinal products from TT is expanding at a remarkable pace among consumers who are attempting to enhance their sexual health. Analysis of phytochemical and pharmacological studies in humans and animals revealed an important role for TT in treating erectile dysfunction and sexual desire problems; however, empirical evidence to support the hypothesis that this desirable effects are due to androgen enhancing properties of TT is, at best, inconclusive, and analysis of empirical evidence from a comprehensive review of available literature proved this hypothesis wrong. While the mechanisms underlying TT aphrodisiac activity remain largely unknown, there is emerging compelling evidence from experimental studies in animals for possible endothelium and nitric oxide-dependent mechanisms underlying TT aphrodisiac and pro-erectile activities.

Blood Sugar influence
Hypoglycemic effect of saponin from Tribulus terrestris
Zhong Yao Cai. 2002. School of Life Science, East China Normal University, Shanghai.
To study the hypoglycemic effect of saponin from Tribulus terrestris. Alloxan was used to establish the diabetic model in mice. Phenformin Hydrochlride Tables was used as the positive control. The level of glucose, triglyceride, cholesterol and SOD in serum were determined. The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26% and 40% in normal mice and diabetic mice in respectively. The level of serum triglyceride could be reduced 23.35%. The saporin could also decrease the content of serum cholesterol. Serum SOD activity of the mice was increased by the saponin. Saponin from Tribulue terrestris could significantly reduce the level of serum glucose.

Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity.
Life Sci. 2003. Department of Pharmacology, Razi Institute for Drug Research and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Tribulus terrestris is a natural herb used for treating many diseases including hypertension. According to previous reports, aqueous extract may have some antihypertensive effect with an unknown mechanism. The present study investigated the antihypertensive mechanism of tribulus in 2K1C hypertensive rats by measurement of circulatory and local ACE activity in aorta, heart, kidney and lung.  The ACE activity in all tissues of 2K1C rats including: aorta, heart, kidney, lung as well as serum were significantly increased compared to normal rats. The ACE activity in all tissues of tribulus fed hypertensive rats was significantly lower than that of hypertensive rats, which was more pronounced in kidney. These results indicated that there is a negative correlation between consumption of tribulus terrestris and ACE activity in serum and different tissues in rats.

Activity of certain fractions of Tribulus terrestris fruits against experimentally induced urolithiasis in rats.
Indian J Exp Biol. 1994. Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
An ethanolic extract of the fruits of T. terrestris showed significant dose dependent protection against uroliths induced by glass bead implantation in albino rats. On subsequent fractionation of the ethanol extract, maximum activity was localised in the 10% aqueous methanol fraction. It provided significant protection against deposition of calculogenic material around the glass bead. It also protected leucocytosis and elevation in serum urea levels. Further, fractionation lead to decreased activity. This could be either due to loss of active compounds during fractionation, or the antiurolithiatic activity of T. terrestris being a combined effect of several constituents present in the methanolic fraction.

I’m taking it as a part of my workout supplements. I’m taking 1000 mg of it, is this safe for my liver and kidneys? I have heard that this plant is great for the liver and kidneys, I just wanted to make sure.
Long term human studies are not available to know the full benefits and side effects. It is a good idea not to use it daily and to take breaks.

Hepatic Effect of Tribulus extract
Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestris: indications of cytoprotective activity in murine hepatocyte culture.
Planta Med. 1998. Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and beta-sitosterol. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D-GalN)/tumor necrosis factor alpha (TNF-alpha).

Effect of Tribulus terrestris on oxalate metabolism in rats.
J Ethnopharmacol. 1994. Department of Biochemistry, Panjab University, Chandigarh, India.
This study concerns the effect of an aqueous extract of Tribulus terrestris on the metabolism of oxalate in male rats fed sodium glycolate. Glycolate feeding resulted in hyperoxaluria as well as increased activities of oxalate synthesizing enzymes of the liver i.e. glycolate oxidase (GAO), glycolate dehydrogenase (GAD) and lactate dehydrogenase (LDH), and decreased kidney LDH activity. T. terrestris administration to sodium glycolate fed rats produced a significant decrease in urinary oxalate excretion, and a significant increase in urinary glyoxylate excretion.

Q. I have enjoyed reading Natural Sex Boosters and have been researching aphrodesiac herbs on the internet as well. I am unable to find evidence for a stimulating effect on testosterone (or on LH ) attributable to tribulus terrestris Is there any supplement that will enhance the conversion of androstenedione (endogenous) to testosterone ?
A. We have not seen enough human research on tribulus terrestris or other aphrodisiac herbs to know what the short term and long term effects are on testosterone secretion or production.

For low testosterone problems, TT is reported to help. Can the plant extract be taken at the same time with Passion Rx?
We suggest alternating their use every other day.

Thyroid function
Could you please tell me any drug interaction with Synthroid (for hypothyroid) Effexor xr (depression & anxiety.
There have not been any studies regarding the combination of tribulus terrestris and Synthroid or Effexor. Small amounts could be fine, but higher amounts could cause side effects. If you plan to use tribulus terrestris, start with a quarter of a capsule.

What’s in the herb?
The fruits of tribulus contain a number of different substances including saponins, glycosides, flavonoids, alkaloids, resins, tannins, sugars, sterols, and essential oil. Recently, two new saponins have been isolated from tribulus terrestris: Terrestrinins A and B, .
A frequently mentioned substance in tribulus is protodioscin, which some claim is one of the active substances within this plant. When different samples of tribulus were analyzed, significant differences in the composition of saponins were observed depending on the origin and plant part used. One analysis of products showed considerable variations of 0.17 to 6.5 % in protodioscin content.

How it works
T extract may work by relaxing smooth muscles and increasing blood flow into the corpus cavernosa. The relaxant effect observed is probably due to the increase in the release of nitric oxide from the endothelium and nerve endings. Since tribulus relaxes smooth muscles, this may account for its benefits in abdominal colic. It may also influence levels of testosterone.

Interactions with medications
I am taking a drug called Bupropion HCL150 SA tab three times a day and my concern was taking the Tribulus with it. Can you advise me of any issues that might occur.
Much depends on the dosage of the medication used and the dosage of the herbal product along with the unique response of the person using them. As a general rule we suggest trying each supplement by itself for a few days before combining, and then doing so with medical approval.

Side effects, adverse reactions
No significant tribulus side effects have yet been reported in the medical literature regarding the human use of tribulus terrestris. However, little is known about the long-term use of tribulus consumption in humans. As with most herbs, it is best to take breaks from use in order to minimize potential long term tribulus side effects.
I have noticed and heard the following tribulus terrestris side effects: more energy, feeling warmer, slightly faster heart beat, restlessness. These side effects are dose dependent. 

Does tribulus have a side effect of blood pressure increase? I have mild hypertension.
We have not seen human studies with tribulus supplements to know for certain whether or not it influences blood pressure. You may consider at first using half a capsule or a capsule every other day and monitor it. We have not had any reports of high blood pressure side effect from the use of tribulus supplements, but we can’t be certain without knowing the results of scientific studies.

Q. I came across your website when looking for more information on Tribulus Terrestris. This is because an extract of this plant is being promoted for ‘stimulating the Hypothalamus’. As I suffer from Narcolepsy, for which the Hypothalamus is responsible, I wondered if Tribulus Terrestris might help? I certainly don’t need an aphrodisiac and don’t know what effect an increase in testosterone would have on me. Should I give Tribulus Terrestris a try to see what effect it has on my narcolepsy? What should I look for in a product in terms of ingredients?
A. There are countless herbs that influence alertness and could keep a person awake, tribulus terrestris is not the only one. Ginseng, ginkgo, acetylcarnitine, dmae, products such as Mind Power Rx and Eyesight Rx all help alertness. It is difficult to predict which one or combinations will help any individual person. We have not seen any specific studies in humans regarding tribulus terrestris and narcolepsy or the long term influence of this herb on the hypothalamic hormones.

Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain.
J Ethnopharmacol. 2005. Department of Obstetrics and Gynaecology, National University Hospital, National University of Singapore, Singapore.
Tribulus terrestris have been used as an aphrodisiac both in the Indian and Chinese traditional systems of medicine. Administration of Tribulus extract increased sexual behaviour and intracavernous pressure both in normal and castrated rats and these effects were probably due to the androgen increasing property of tribulus terrestris. The objective of the present study is to evaluate the effect of Tribulus terrestrison nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and androgen receptor (AR) immunoreactivity in rat brain. There was an increase in both NADPH-d and AR immunoreactivity in Tribulus treated group and these results were statistically significant compared to the control. Chronic treatment of Tribulus terrestris in rats increases the NADPH-d positive neurons and AR immunoreactivity in the PVN region. Androgens are known to increase both AR and NADPH-d positive neurons either directly or by its conversion to oestrogen. The mechanism for the observed increase in AR and NADPH-d positive neurons in the present study is probably due to the androgen increasing property of tribulus terrestris. The findings from the present study add further support to the aphrodisiac claims of tribulus terrestris.

Q. i am a male 30 years old. i was treated for 5 weeks by dompridone 10mg 3 times per day and nizatidine 150 mg twice daily ( as a treatment of gastric reflux) after which i had a low or zero libido and a very weak morning erection. Both drugs can cause hyper prolactinemia and anti androgenic effect. I thought that it may be a hyperprolactinemia but it was not i had a normal LH – PRL – Testosteron – Free Testosteron. Dompridone as a dopaminergic blocker can cause low libido state and nizatidine h2 receptor blocker has anti androgenic effect. i stopped these drugs one year ago but believe me no improvement in morning erection and no improvement in libido at all. i consult many andrologists and endocrinologists and no explanation now I am on tribulus 250 mg cap 3 times daily. What is proper dose of tribulus supplement.
A. Tribulus comes in varied extract concentrations, therefore not knowing the actual extract potency is difficult for us to say. If it is plain tribulus powder and not concentrated, a dose of 500 to 1000 mg a day is okay to take, and it does not have to be tapered before stopping.

I would like to know if you have any research on a product called Tribulus Aquaticus (stem and leaf, Its in a bodybuilding product from usp labs called PRIME. Suposibly it does not raise testosterone levels like normal Tribulus, the company claims that it works as a nutrient delivery agent of some sort, I can say that my strength in the gym went up significantly from only taking this product even more that when I took TT but I definitely feel as if my test levels are elevated due to aggression.
We are not familiar with this product. A search on Meldine in May 2010 did not reveal any studies with tribulus aquaticus.