Galantamine benefit and side effects, available as a dietary pill and as a prescription medication
Alzheimer’s disease treatment, proper dosage, interactions with medications, a review of side effects
and adhd, autism, choline, alcohol, lucid dreaming, nightmares, bipolar, contraindications
March 1 2016
Galantamine is a cholinergic medicine. It can be isolated from several plants, including daffodil bulbs, but is now synthesized. It is available over the counter and also by prescription. It is a cholinesterase inhibitor and allosteric potentiating ligand modulating presynaptic nicotinic acetylcholine receptors.
Galantamine offsets reductions in central cholinergic neurotransmission in Alzheimer’s disease by specifically and reversibly inhibiting acetylcholinesterase. This allows more acetylcholine to be available in the brain. It is also a nicotinic receptor agonist. Another herbal extract that has potential in the therapy of Alzheimer’s disease is Huperzine A. Research studies are published on a regular basis and this web page will update these studies as they related to Alzheimer’s disease. Side effects will be discussed along with prescription Reminyl for dementia and how other medications used for AD interact with over the counter galantamine supplements.
Galantamine side effects, safety, danger
Side effects are similar to those of other cholinesterase inhibitors, i.e. nausea, vomiting, diarrhea, abdominal pain, and dyspepsia. Keep your dosage low.
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A formulation featuring galantamine, a phytonutrient extracted from the common snowdrop (Galanthus nivalis), daffodil (Narcissus pseudonarcissus L.), and spider lily (Lycoris radiata), among other plants.
As an acetylcholinesterase inhibitor, it competitively blocks the premature, age-related breakdown of the natural neurotransmitter acetylcholine, an essential molecule that supports memory function. Unlike other acetylcholinesterase inhibitors, it also enhances nicotinic receptor activity, an effect long known to influence memory and intellectual activity.
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Suggested Use: For adults only. Half or one galantamine capsule in the morning a few times a week with breakfast
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Also contains the nutrients choline and pantothenic acid, the precursor and cofactor, respectively, to the body’s production of acetylcholine.
How is it made, where does it come from?
Can you tell me whether the galantamine supplement is synthetic or extracted from plants or a combination? If extracted, what plants?
Galantamine is naturally extracted from the common snowdrop (Galanthus nivalis), daffodil (Narcissus pseudonarcissus), and spider lily (Lycoris radiata).
Alzheimer’s disease research
Being approved for the treatment of Alzheimer’s disease in both the US and in Europe, galantamine has potential as therapy for dementia. Galantamine is currently not recommended for use by young individuals.
Effects of Galantamine on Measures of Attention: Results From 2 Clinical Trials in Alzheimer Disease Patients With Comparisons to Donepezil.
Alzheimer Dis Assoc Disord. 2008.
Subjects with Alzheimer’s disease were tested comparing the effects of galantamine, an acetylcholinesterase inhibitor and postulated nicotinic receptor modulator, and donepezil, an acetylcholinesterase inhibitor. Attention task performance tended to improve early for galantamine treated subjects. A consistent temporal pattern of improvement was not observed in donepezil-treated subjects. Quantitative findings appeared more pronounced in subjects with moderate Alzheimer’s disease. Galantamine’s proposed action as a nicotinic receptor modulator may bear on these findings.
The cognitive benefits of galantamine are sustained for at least 36 months: a long-term extension trial.
Raskind MA. University of Washington School of Medicine Seattle, USA.
Arch Neurol. 2004.
Subjects were 194 US patients with mild to moderate AD who had been randomized to continuous galantamine therapy in either of 2 double-blind placebo-controlled trials. Subjects subsequently received open-label continuous therapy for up to 36 months. Effects on cognition were analyzed as change from study enrollment baseline in scores on the Alzheimer’s Disease Assessment Scale-11-item cognitive subscale. Cognitive decline in galantamine-treated subjects was compared with that in a clinically similar historical control sample of AD patients who had received placebo for 12 months and with the mathematically predicted decline of untreated patients over 36 months. The rate of cognitive decline of patients who completed the entire 36-month trial was compared with that of patients who withdrew for any reason during the long-term open-label extension. An inverted responder analysis was also performed in 36-month completers. Patients treated continuously with galantamine for 36 months increased a mean of 10 points on the Alzheimer’s Disease Assessment Scale-11-item cognitive subscale-a substantially smaller cognitive decline (approximately 50%) than that predicted for untreated patients. Patients discontinuing galantamine therapy before 36 months had declined at a similar rate before discontinuation as those completing 36 months of treatment. Almost 80% of patients who received galantamine continuously for up to 36 months seemed to demonstrate cognitive benefits compared with those predicted for untreated patients. Cognitive decline over 36 months of continuous galantamine treatment was substantially less than the predicted cognitive decline of untreated patients with mild to moderate dementia. Thus, the cognitive benefits of galantamine seemed to be sustained for at least 36 months. These findings suggest that galantamine slows the clinical progression of AD.
Efficacy and safety of galantamine in patients with dementia with Lewy bodies: a 24-week open-label study.
Dement Geriatr Cogn Disord. 2007.
Dementia with Lewy bodies is a common dementia of the elderly. A significant cholinergic deficit has been demonstrated that may be responsive to treatment by cholinesterase inhibitors. A 24-week, open-label study was designed to assess the efficacy and safety of galantamine in 50 patients with dementia. Galantamine appears to be an effective and safe therapy for patients with Lewy boy dementia.
Dosage and availability over the counter
Does galantamine supplement come in 12 mg dosage?
We only find it in 4 mg. There could be adverse effects on higher dosages.
Combining with other dietary supplements and herbs. combination with dietary supplements, interactions
Is there a danger combining tongkat ali herb with galantamine pill?
Yes, it could lead to sweating and severe insomnia.
Is it safe to take it along with sam e for arthritis pain and Diet Rx.
They are both potent supplements and we prefer users not take them the same day.
Can you ship galantamine to Europe, to Belgium? I’ve been in trouble for shipping melatonin before.
We have not had this product returned by customs, but we can’t predict what customs will do sometimes in foreign countries.