Clozapine risk and danger with overdose or prolonged usage
November 1 2016

Clozapine is a pharmaceutical drug also known as Clozaril. It is an antipsychotic medication. Perhaps the use of ashwagandha herbal therapy can lessen the adverse effects of the use of this antipsychotic.

Clozapine risk and danger
Myocarditis is a rare but life threatening risk that can occur after use. Some symptoms of myocarditis – elevated temperature, tachycardia and fatigue – appear commonly during the onset of treatment with clozapine and during the dose titration.

Clozapine not helpful with risperidone
A double-blind study of combination of clozapine with risperidone in patients with schizophrenia: effects on cognition.
J Clin Psychiatry. 2006.
Atypical antipsychotic drugs produce improvement in some domains of cognition as well as psychopathology in patients with schizophrenia. However, the effect of combinations of atypical antipsychotic drugs on cognitive function is unknown. The aim of this study was to compare the effect of risperidone or placebo on cognitive function in patients with schizophrenia who were previously treated with clozapine monotherapy. This prospective, randomized, double-blind, placebo-controlled, 6-week study included 30 patients with DSM-IV schizophrenia. Patients whose psychopathology was no more than partially responsive to clozapine treatment were randomly assigned to receive adjunctive treatment with risperidone up to 6 mg/day or placebo. Cognitive test scores for verbal learning and memory, verbal fluency, attention, executive function, verbal working memory, and motor function were the primary outcome measures. Secondary outcome measures included assessment of psychopathology, extrapyramidal side effects, and global functioning. Adjunctive treatment with risperidone for 6 weeks in patients with schizophrenia who had received chronic treatment with clozapine does not significantly improve cognitive function.

Clozapine and heart damage, harm to the cardiovascular system
Clozapine-Associated Myocarditis : A Review of 116 Cases of Suspected Myocarditis Associated with the Use of Clozapine in Australia During 1993-2003.
Drug Saf. 2007. NHMRC Centre of Clinical Research Excellence in Therapeutics, Faculty of Medicine, Nursing & Health Sciences, Monash University, Alfred Hospital, Melbourne, Victoria, AustraliaPharmacy Department, Alfred Hospital, Melbourne, Victoria, Australia. Department of Epidemiology & Preventive Medicine, Medication Safety Group, Faculty of Medicine, Nursing & Health Sciences, Monash University, Alfred Hospital, Melbourne, Victoria, Australia.
Clozapine is an antipsychotic medication associated with a lower suicide rate compared with other antipsychotic agents. Clozapine is used specifically in patients for whom previous therapy was inadequate or not tolerated, and is the only antipsychotic agent associated with the development of myocarditis. To retrospectively review all adverse drug reaction reports voluntarily submitted to the Australian Adverse Drug Reactions Unit mentioning suspected myocarditis in clozapine-treated patients. We accessed all electronic database entries and case reports citing suspected myocarditis associated with clozapine therapy from January 1993 through to December 2003, inclusive. Clozapine is uncommonly but importantly related to myocarditis, often fatal or near fatal and sometimes in relatively young patients with early onset after treatment initiation. The most striking feature about this condition is the wide diversity of nonspecific symptoms that occur in afflicted patients. Additional pharmacovigilance, improved reporting systems and further investigation of mechanisms of drug-induced myocarditis and related cardiovascular conditions (such as heart failure) are clearly warranted. A case-control study would be suitable for investigation of baseline predictors.

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