Benefit for cancer
Beta-carboline alkaloids isolated from tongkat ali have demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines. In plain English, this means that some compounds in Tongkat ali can kill cancer cells. The practical significance of this finding in humans is not clear at this time. Tongkat ali supplements can cause side effects if used daily in high dosages, so we don't know if small amounts of the supplements could have an anti-cancer benefit.

f
Fertility and infertility, sperm health
The effect of Eurycoma longifolia on sperm quality of male rats.
Nat Prod Commun. 2009 Oct; Chan KL, Low BS, Teh CH, Das PK. School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
The present study investigated the effects of a standardized methanol extract of Eurycoma longifolia Jack containing the major quassinoid constituents of 13alpha(21)-epoxyeurycomanone, eurycomanone, 13alpha,21-dihydroeurycomanone and eurycomanol on the epididymal spermatozoa profile of normal and Andrographis paniculata induced infertile rats. The standardized MeOH extract at doses of 50, 100 and 200 mg/kg, the EtOAc fraction (70 mg/kg), and standardized MeOH extract at 200 mg/kg co-administered with the EtOAc fraction of A. paniculata at 70 mg/kg were each given orally to male Sprague-Dawley albino rats for 48 consecutive days. The results showed that the sperm count of rats given the standardized MeOH extract alone were increased compared with that of control). The low count, poor motility and abnormal morphology of the spermatozoa induced by the A. paniculata fraction were significantly reversed by the standardized MeOH extract of E. longifolia. The plasma testosterone level of the rats treated with the standardized MeOH extract at 200 mg/kg was significantly increased when compared with that of the control and infertile animals. The spermatocytes in the seminiferous tubules and the Leydig cells appeared normal. Testosterone level was significantly higher in the testes than in the plasma after 30 days of oral treatment with the standardized MeOH extract. Interestingly, eurycomanone alone was detected in the rat testis homogenates and may have contributed towards the improvement of sperm quality. Thus, the plant may potentially be suitable for the management of male infertility.

Use for malaria
Interestingly, scientists have found that, in addition to its sex-enhancing effects, compounds within this root have anti-malarial properties.

Influence on testosterone levels
Will this product boost testosterone levels that aid in building muscle mass?
    TA may boost testosterone levels, but it is not clear whether it does so consistently over time and even less is known whether taking TA helps with muscle growth. This herb has quite a number of side effects and it is not a reliable way to increase T levels. I

Mechanism of action
Little is known regarding the mechanisms of action of tongkat ali extract. Recent studies indicate that the root contains several compounds including beta-carboline alkaloids and quassinoid-type glycosides, including eurycomaoside. How these compounds and many others in tongkat ali root influence hormonal release or the human sexual response is not clearly understood at this time but it appears, at least in rodent studies, that the administration of this herb increases testosterone output. We have read promotional material by some vitamin companies regarding tongkat ali extract that it enhances testosterone production or release, and this appears to have some validity.

Availability and dosage
Tongkat Ali is sold as a powder, in capsules, sometimes mixed with other herbs. There are a number of tongkat ali extracts available in various potencies, and since each company has a different way of extracting, and since there are no established standards, it is difficult to give dosage recommendations that would be consistently effective with few side effects. In addition to being available as a raw powder, it is sold in extracts as a 4:1, 5:1, 20:1 and a 100:1 concentration. At the higher concentrations it becomes difficult to dose appropriately since the margin of error in terms of effectiveness versus side effects becomes more challenging. There are companies that claim they have a 200 to or even a 400 to 1 extract. Many researchers who are experts on this topic doubt the integrity of these claims. They could be selling just a 2 to 1 or perhaps a 10 to 1 extract, mixing it with other herbs, but calling it 200 to 1. If the company you are buying from has an overseas address or no physical location in the US, be suspicious.
 

What is the ideal dosage?
Although high dosages of tongkat ali work quicker, they also can produce unpleasant side effects. Hence, we suggest starting at a lower amount, such as 200 mg of tongkat ali root powder, and to use this amount every other day or two days on, one or more days off. Use a lower amount if you live in a hot climate since this herb can raise body temperature.

Side effects, danger, adverse events, how safe is it?
One of the shortcomings of Tongkat Ali is that it can easily cause insomnia, and lack of sleep can lower sex drive. Therefore it is somewhat difficult to find the right dose that works without causing this insomnia, and that's where an experienced herbalist who has wide knowledge with this plant is crucial in terms of formulating the right product with the right amount and extract potency of tongkat ali. High doses can also cause increased body temperature. Some people find that when they take a high dose, they become restless and impatient, perhaps easily angered. Long term effects of tongkat ali on human consumption are not known. It is best, until we learn more, to not take it continuously without breaks. Some people prefer tongkat ali every other day, or 2 days on, 2 days off, or just a couple of days a week. In fact, taking tongkat ali 2 days a week minimizes any potential side effects.

Tongkat Ali eurycoma longifolia questions
Q. Is it possible that chronic use, increasing over time due to tolerance, of OTC herbals such as tribulus terrestris, tongkat ali, etc. can lead to secondary hypogonadism due, such as the HTPA axis being so imbalanced that it cannot easily be restarted?
   A. The hormonal influence of tongkat ali, tribulus terrestris, and many other herbs, when used on a chronic basis, is not fully known since human studies are few, but this, and other scenarios, are theoretically possible. We always recommend people take breaks from the use of herbs. In most people, tongkat ali only needs to be taken 2 or 3 days a week.
 

What is the difference in strength between tongkat ali 200 mg and LJ100:1 25 mg?
     It's difficult to say, some people prefer LJ100 25 mg while we have feedback for just the opposite, others preferring tongkat ali 200 mg powder.
 

Q.  I have been taking tablets of 80 mg LJ100 but I am also considering tongkat ali root powder, 200mg capsules. I need to know what the ratio this product is based on so i know how many tablets equals the dosage i am presently taking.
   A. Herbs are available as the regular full spectrum powder and also in various extract potencies. There is a misconception that if an extract is 10:1 that means it is 10 times as potent, or if it is 100:1 then it is 100 times more potent, but that is not the case. When an herb is concentrated, sometimes some of the other active ingredients are removed since the manufacturers focus on a particular substance within an herb rather than the full spectrum of potential beneficial substances. Many people find full spectrum tongkat ali 200 mg regular powder to be a good amount and more is not necessarily better. We often suggest using less tongkat ali since side effects occur on high doses including disturbed sleep and high body temperature and irritability. If insomnia occurs, that can take away the benefits of the sexual enhancement since sleep is important for optimal libido. Most people prefer taking onecapsule of tongkat ali 200 mg every other day, or two days on, 1 or 2 days off. Taking days off actually makes this aphrodisiac herb work better. As to LJ100, high doses, such as over 25 mg, may work well, but also cause unpleasant side effects. Dr. Ray Sahelian has formulated a product at 25 mg of LJ100 in order to minimize unpleasant effects.

Q. How quickly does tongkat ali or LJ100 work? Can they be used the same day as Viagra?

   A. Herbs are not like drugs, they take a few days before providing optimal results. You can take one capsule LJ100 in the morning every other day or 3 days a week. We suggest not taking Viagra the same day as LJ100. Viagra can be taken on a day when you are not taking LJ100 and it is better to use a smaller dose of Viagra than you normally do. LJ100 and many other herbs have a delayed effect into the second and third day after taking a capsule.

Q. Do you have a tongkat ali eurycoma longifolia picture?
   A. We are in the process of finding a high resolution tongkat ali picture.
 

I tried the coffee version and was impressed by the feverish feeling it gave me. It is not a pleasant thing to take in an un-air conditioned apartment in Saigon, Vietnam.

I am a 24 year old male from the UK. I had my testosterone levels checked and they were 13 nmol/L. Very low! Although the medical normal range is about 9nmol/L to 38nmol/L, my low level is causing problems for me. Particularly I believe it is hindering muscle gains in the gym, causing more fat storage and lowering the quality of my erections (strength and duration). I also believe it is negatively affecting my penile size. Also a lack of facial hair! I want to boost my testosterone levels. I understand you cannot give me specific advice, and I am currently in conference with my doctor over these issues, and hope to see an endocrinologist to have a thorough examination to search for possible causes of my low level. I was however hoping you may be able to give me some general advice on low testosterone and testosterone boosters. Particularly Tongkat Ali. I came across a website claiming than most tongkat ali products are really pretty useless due to chronic underdosing of the actual active ingredients and poor quality plants (too young and/or contaminated with heavy metals). I hear that Malaysian tongkat is inferior and really Indonesian tongkat is the only one worth buying. I am seriously considering buying some 1:50 tongkat ali extract from Indonesia. However I am worried about taking this pure high dose stuff, as I hear it has an LD50 value (a dosage value where 50% of the lab animals died from)...I am not familiar with an LD50 and if all or most herbal products have one, but I found it quite scary that tongkat could be lethal to life at ANY dosage however high. And to me an LD50 is not a safe guarantee level, a safe level would be under the dosage where ANY lab animal died, preferably lower than where any serious negative side effects were noted! Also, I am hoping to try and increase my penile size with tongkat ali, I hear it can do this, particularly with ballooning techniques applied to the penis. One website claimed that it is not the actual testosterone (and then the increased metabolite of testosterone-dihydrotestosterone) increase which increases penile size but the increased activity of the leydig cells in the testicles which causes the testicles and penis to increase in size, and this is why exogenous steroid usage shrinks the penis. I can see how increased leydig cell activity could increase the testicles but I dont see how it could increase the size of the penis...but it would be worth a try, and if it works it works, I dont care if people dont understand WHY or HOW it works, as long as its safe! I am unsure if this would mean I would need an even higher dosage of tongkat, hopefully this would still be safe? Finally I am worried about the claims tongkat can make you more aggressive and more sexual. I guess its the fear I may lose control of my actions (similar to the cases of roid rage, particularly cases where people end up in jail for loss of control!) Is this a serious concern with tongkat ali, in high doses of 1:50 extract. I believe the dosage is about 1 gram a day. Many thanks for your time, please get back to me if you have the time, it would really mean alot to me, as there are few places to turn for quality advice on herbal products.
    There are many websites that have incomplete or incorrect information regarding this herb, especially as to which country is a better source. Both Malaysia and Indonesia have good tongkat ali trees and be skeptical of web sites that try to sell their product claiming theirs is the best. Hopefully this page will help you with the right info. If you plan to use this herb, use low dosages and take frequent breaks.
 

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Tongkat ali supplement emails
Q. Before I buy tongkat ali extract, I would like to know if it interferes with heart medications or is safe for someone with heart disease.
   A. This root, in high doses, can increase heart rate, and in very high doses could cause heart rhythm problems. This would not be a major problem in those who have normal hearts since the effects are temporary, but in those who have heart disease, unexpected complications could occur. Hence, we don't suggest you buy tongkat ali if you have a heart condition.

Q. I read somewhere that tongkat ali causes penis size enlargement. What is the influence of this herb on penis size and growth?
   A. Tongkat ali can help with improving penis blood flow, but it will not help your penis grow bigger than it would normally under maximal and ideal stimulation. In other words, this aphrodisiac plant can help your penis engorge to the maximum it would if you were quite stimulated, but it is not going to make your penis grow an inch or two.

Q. I understand in southeast Asia. like Indonesia or Malaysia, they drink tongkat ali coffee, is this true? If so, can I mix tongkat ali powder in my coffee?
   A. Yes, in Malaysia, Indonesia, and Thailand they do drink tongkat ali coffee. You can mix the root powder in your coffee but we don't see any advantage to doing this. Coffee is a stimulant, so is tongkat ali. Plus, this root does not taste that well, it fact it is quite bitter.

Q. What are your thoughts regarding the use of tongkat ali for bodybuilding purposes since this root extract may stimulate testosterone?
   A. We prefer using more effective supplements for body building such as creatine and protein powders.

Q. Do you have tongkat ali reviews of the different products on the internet?
   A. There are dozens of companies that sell eurycoma longifolia products. We have not done a review of the different supplements to see how effective they are. Some products have too high a dosage of tongkat ali and if you do purchase them, use a portion of a capsule.

Q. Is it okay to take extracts of tongkat ali and ginseng the same day?
   A. Both of these herbs are potent, and they are fine to take together only in very small dosages, otherwise you are likely to get insomnia.

Q. Can I open a capsule of tongkat ali extract and make tea out of it?
   A. You can, but this root has a bitter taste.
 

Q. Can women use tongkat ali? Does this root enhance sexuality in a woman?
   A. Yes, but since women are smaller, the dosage would be less.
 

Q. Is tongkat extract safe to take with antidepressant medications such as SSRIs?
   A. Tongkat ali may not be safe to take along with SSRI medications such as Prozac or Paxil. Tongkat ali is a potent herb and could cause rapid heart beat, increased body temperature, restlessness, or other side effects when combined with medicines that that have an influence on neurotransmitters. If your doctor approves, you may wish to skip your depression medication during the days that you take tongkat extract.

Q. I was reading your website regarding tongkat ali It says to take the capsules or power in single doses. I had bought SD-50 Eurycoma Longifolia Jack Extract Strength 1:50 . it says to take 3 capsules in the morning before food. Would this be safe or is it too much?
   A. SD-50 is a tongkat ali extract that we have not taken ourselves so we don't know how potent it is.
 

Does tongkat ali increase testosterone levels?
   As of April 2010, we have come across only limited human research regarding the influence of this herb on testosterone levels. Even if this herb helps make, or release, testosterone, would the effects continue over time? The answers are not clear at this time. We do know that taking a tongkal ali supplement helps increase libido and genital sensation, along with orgasm strength. Are these due to testosterone release or due to other factors?

I wrote you the other day after purchasing LJ 100 extract and I questioned the dosage. I certainly don't want to take this improperly but as i do more and more research I,m finding numerous indications that a 25 mg dose of extract won't do anything. Like I said, I feel i desperatley need a testosterone boost, I don't want to overdose but I would like to see results and of course I don't want to waste my money. The following is an example of what I keep coming across as I'm doing my research. "The Rest: LJ100, Ray Sahelian. Now this is going to sound biased but really it isn't and if you are to follow along my simple line of reasoning, you will very likely agree with me. I avoid most of the other products in the marketplace. Not because they are inferior but simply because they are 'insufficient'. Now what do I mean by this? One capsule of SD-200 contains 300 mg of extract. One capsule of Indonesia Tongkat Ali contains 400 mg of extract. If you look at LJ 100 or Ray Sahelian, one capsule contains 25 mg. I'm sorry but that amount just ain't going to cut it. If you eat 10 burgers but the size of each burger is the size of an M&M chocolate, of course you are still going to feel hungry. Now, if you take 20 capsules at a time, it may work but it just don't seem very practical and if you are to add up the cost, it is actually more expensive than SD-200!By the way, LJ100 and Ray Sahelian's Tongkat Ali products are alcohol based extraction. And if you really want to try out alcohol based pure extract, I recommend Indonesia Tongkat Ali. Its less expensive when you consider the total gram you are receiving. As a matter of fact, I encourage you to do that. So that you my readers can give me feedback on how well Indonesia Tongkat Ali alcohol base extract is working for you. And if enough rave reviews come in, I will follow my own sage suggestion and take both Indonesia Tongkat Ali and SD-200."
    Dr. Sahelian is a trusted source in this matter and as we said before there is dangerous misinformation on this topic on the internet by those who wish to promote their product at the expense of others. People can get serious side effects on very high dosages and it is better to enhance the effects gradually than get these adverse reactions. Many people have followed the advice on other web sites and have regretted it. Promoters who try to make money criticizing other products are inherently not to be trusted. Also, it is important to find out whether they have a physical office in the United States or they operate from a mailbox or from overseas. There is nothing we can say that will convince you unless you try the different products and find out for yourself. If you do not wish to open the bottle you purchased, you are welcome to return it, please see the Physician formula website for the return policy.

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This web site is maintained by P. Bradford. The contact address is pbgresearch at yahoo
 

I am a 62 year old male bodybuilder (no steroids) and am currently taking 50mg DHEA per day and have done for a number of years. I am considering also supplementing with Tongkat Ali root powder 200 mg. Can you advise me about a safe dosage regime for this combination?
    Both DHEA and the aphrodisiac herb are potent supplements and should be used with caution. We do not suggest using more than 3 capsules a week of the herb and not the same day as the hormone.

To learn more about this herb for sexual health improvement, see You Tube http://www.youtube.com/watch?v=jO9PHdGai9o